| Title |
The Residual Innate Lymphoid Cells in NFIL3-Deficient Mice Support Suboptimal Maternal Adaptations to Pregnancy
|
|---|---|
| Published in |
Frontiers in immunology, February 2016
|
| DOI | 10.3389/fimmu.2016.00043 |
| Pubmed ID | |
| Authors |
Selma Boulenouar, Jean-Marc Doisne, Amanda Sferruzzi-Perri, Louise M. Gaynor, Jens Kieckbusch, Elisa Balmas, Hong Wa Yung, Shagayegh Javadzadeh, Léa Volmer, Delia A. Hawkes, Keli Phillips, Hugh J.M. Brady, Abigail L. Fowden, Graham J. Burton, Ashley Moffett, Francesco Colucci |
| Abstract |
Uterine NK cells are innate lymphoid cells (ILC) that populate the uterus and expand during pregnancy, regulating placental development and fetal growth in humans and mice. We have recently characterized the composition of uterine ILCs (uILCs), some of which require the transcription factor NFIL3, but the extent to which NFIL3-dependent cells support successful reproduction in mice is unknown. By mating Nfil3 (-/-) females with wild-type males, here we show the effects of NFIL3 deficiency in maternal cells on both the changes in uILCs during pregnancy and the downstream consequences on reproduction. Despite the presence of CD49a(+)Eomes(-) uILC1s and the considerable expansion of residual CD49a(+)Eomes(+) tissue-resident NK cells and uILC3s in pregnant Nfil3 (-/-) mice, we found incomplete remodeling of uterine arteries and decidua, placental defects, and fetal growth restriction in litters of normal size. These results show that maternal NFIL3 mediates non-redundant functions in mouse reproduction. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 25% |
| United Kingdom | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Greece | 1 | 1% |
| Unknown | 67 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 25% |
| Student > Bachelor | 13 | 19% |
| Student > Master | 8 | 12% |
| Researcher | 5 | 7% |
| Student > Doctoral Student | 4 | 6% |
| Other | 6 | 9% |
| Unknown | 15 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 13 | 19% |
| Agricultural and Biological Sciences | 12 | 18% |
| Medicine and Dentistry | 10 | 15% |
| Biochemistry, Genetics and Molecular Biology | 10 | 15% |
| Nursing and Health Professions | 1 | 1% |
| Other | 3 | 4% |
| Unknown | 19 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 March 2016.
All research outputs
#15,542,258
of 25,411,814 outputs
Outputs from Frontiers in immunology
#15,154
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Outputs of similar age
#159,897
of 312,165 outputs
Outputs of similar age from Frontiers in immunology
#73
of 147 outputs
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